Anti-Recombinant-FADS1/Delta 5 desaturase antibody [RM1E55] (STJA0023049)

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STJA0023049
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC/IF/IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Acyl-Coa is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1E55
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: FADS1
Gene ID: 3992
Uniprot ID: FADS1_HUMAN
Function Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6). Isoform 2: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Protein Name Acyl-Coa
8-3-Desaturase
Delta(5 Fatty Acid Desaturase
D5d
Delta(5 Desaturase
Delta-5 Desaturase
Fatty Acid Desaturase 1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2046105
Reactome: R-HSA-2046106
Cellular Localisation Isoform 1: Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Mitochondrion
Isoform 2: Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Acyl-Coa antibody
Anti-8-3-Desaturase antibody
Anti-Delta(5 Fatty Acid Desaturase antibody
Anti-D5d antibody
Anti-Delta(5 Desaturase antibody
Anti-Delta-5 Desaturase antibody
Anti-Fatty Acid Desaturase 1 antibody
Anti-FADS1 antibody
Anti-FADSD5 antibody

Information sourced from Uniprot.org

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