| Function | Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids. |
| Protein Name | Fatty-Acid Amide Hydrolase 1Anandamide Amidohydrolase 1Fatty Acid Ester HydrolaseOleamide Hydrolase 1 |
| Database Links | Reactome: R-HSA-2142753 |
| Cellular Localisation | Endomembrane SystemSingle-Pass Membrane ProteinCytoplasmCytoskeletonSeems To Be Attached To Intracellular Membranes And A Portion Of The Cytoskeletal Network |
| Alternative Antibody Names | Anti-Fatty-Acid Amide Hydrolase 1 antibodyAnti-Anandamide Amidohydrolase 1 antibodyAnti-Fatty Acid Ester Hydrolase antibodyAnti-Oleamide Hydrolase 1 antibodyAnti-FAAH antibodyAnti-FAAH1 antibody |
Information sourced from Uniprot.org
