| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| Protein Name | DysferlinDystrophy-Associated Fer-1-Like ProteinFer-1-Like Protein 1 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle MembraneColocalizesDuring Muscle DifferentiationWith Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A MyotubeWounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma MembraneColocalizes With AhnakAhnak2 And Parvb At The Sarcolemma Of Skeletal MuscleDetected On The Apical Plasma Membrane Of The SyncytiotrophoblastReaches The Plasmma Membrane Through A Caveolin-Independent MechanismRetained By Caveolin At The Plasmma MembraneWith Cacna1s In The T-Tubule System Of MyotubulesAccumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites |
| Alternative Antibody Names | Anti-Dysferlin antibodyAnti-Dystrophy-Associated Fer-1-Like Protein antibodyAnti-Fer-1-Like Protein 1 antibodyAnti-DYSF antibodyAnti-FER1L1 antibody |
Information sourced from Uniprot.org
