| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Dedicator Of Cytokinesis Protein 2 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM2J39 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | DOCK2 |
| Gene ID: | 1794 |
| Uniprot ID: | DOCK2_HUMAN |
| Function | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. |
| Protein Name | Dedicator Of Cytokinesis Protein 2 |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-983231 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinCytoplasmCytoskeletonColocalizes With F-Actin |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 2 antibodyAnti-DOCK2 antibodyAnti-KIAA0209 antibody |
Information sourced from Uniprot.org
