Anti-Recombinant-DCP1A antibody [RM2Q34] (STJA0026394)

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STJA0026394
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Host: Rabbit
Applications: FC/IF/IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Mrna-Decapping Enzyme 1a is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2Q34
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: DCP1A
Gene ID: 55802
Uniprot ID: DCP1A_HUMAN
Function Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
Protein Name Mrna-Decapping Enzyme 1a
Smad4-Interacting Transcriptional Co-Activator
Transcription Factor Smif
Database Links Reactome: R-HSA-430039
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-975957
Cellular Localisation Cytoplasm
P-Body
Nucleus
Co-Localizes With Nanos3 In The Processing Bodies
Predominantly Cytoplasmic
In Processing Bodies (Pb)
Nuclear
After Tgfb1 Treatment
Translocation To The Nucleus Depends On Interaction With Smad4
Alternative Antibody Names Anti-Mrna-Decapping Enzyme 1a antibody
Anti-Smad4-Interacting Transcriptional Co-Activator antibody
Anti-Transcription Factor Smif antibody
Anti-DCP1A antibody
Anti-SMIF antibody

Information sourced from Uniprot.org

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