Anti-Recombinant-CTSD/Cathepsin D antibody [RM1B33] (STJA0026803)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Cathepsin D Cleaved Into-Cathepsin D Light Chain-Cathepsin D Heavy Chain for use in FC, IF, IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1B33 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CTSD |
| Gene ID | 1509 |
| Uniprot ID | CATD_HUMAN |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. Undergoes proteolytic cleavage and activation by ADAM30. As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified. |
| Function | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
| Protein Name | Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-2022377Reactome: R-HSA-2132295Reactome: R-HSA-6798695Reactome: R-HSA-77387Reactome: R-HSA-9018519 |
| Cellular Localisation | LysosomeMelanosomeSecretedExtracellular SpaceIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvIn Aortic SamplesDetected As An Extracellular Protein Loosely Bound To The Matrix |
| Alternative Antibody Names | Anti-Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain antibodyAnti-CTSD antibodyAnti-CPSD antibody |
Information sourced from Uniprot.org