Host: |
Rabbit |
Applications: |
IHC/IP/WB |
Reactivity: |
Human/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : |
Rabbit monoclonal antibody anti-Recombinant-Muscarinic Acetylcholine Receptor M2 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality : |
Monoclonal |
Clone ID : |
RM1L46 |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.01M PBS |
Purification: |
Protein A/G purified from cell culture supernatant |
Dilution Range: |
IHC: 1:50-1:100 |
Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol. |
Protein Name | Muscarinic Acetylcholine Receptor M2 |
Database Links | Reactome: R-HSA-390648Reactome: R-HSA-418594Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePhosphorylation In Response To Agonist Binding Promotes Receptor Internalization |
Alternative Antibody Names | Anti-Muscarinic Acetylcholine Receptor M2 antibodyAnti-CHRM2 antibody |
Information sourced from Uniprot.org