| Post Translational Modifications | Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells. Dephosphorylated by PDXP/chronophin.this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2. |
| Function | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes. Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration. |
| Protein Name | Cofilin-118 Kda PhosphoproteinP18Cofilin - Non-Muscle Isoform |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-2029482Reactome: R-HSA-3928662Reactome: R-HSA-399954Reactome: R-HSA-5627117Reactome: R-HSA-8950505 |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideLamellipodium MembraneLamellipodiumGrowth ConeAxonColocalizes With The Actin Cytoskeleton In Membrane Ruffles And LamellipodiaDetected At The Cleavage Furrow And Contractile Ring During CytokinesisAlmost Completely In Nucleus In Cells Exposed To Heat Shock Or 10% Dimethyl Sulfoxide |
| Alternative Antibody Names | Anti-Cofilin-1 antibodyAnti-18 Kda Phosphoprotein antibodyAnti-P18 antibodyAnti-Cofilin - Non-Muscle Isoform antibodyAnti-CFL1 antibodyAnti-CFL antibody |
Information sourced from Uniprot.org
