Anti-Recombinant-CENPA antibody [RM1X42] (STJA0024719)

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STJA0024719
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Histone H3-Like Centromeric Protein A is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1X42
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CENPA
Gene ID: 1058
Uniprot ID: CENPA_HUMAN
Function Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
Protein Name Histone H3-Like Centromeric Protein A
Centromere Autoantigen A
Centromere Protein A
Cenp-A
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-606279
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Nucleus
Chromosome
Centromere
Localizes Exclusively To Sites Of Kinetochore Assembly In Centromeres
Occupies A Compact Domain At The Inner Kinetochore Plate Stretching Across 2 Thirds Of The Length Of The Constriction But Encompassing Only One Third Of The Constriction Width And Height
Phosphorylation At Ser-68 During Early Mitosis Abolishes Association With Chromatin And Centromeres And Results In Dispersed Nuclear Location
Alternative Antibody Names Anti-Histone H3-Like Centromeric Protein A antibody
Anti-Centromere Autoantigen A antibody
Anti-Centromere Protein A antibody
Anti-Cenp-A antibody
Anti-CENPA antibody

Information sourced from Uniprot.org