| Host: |
Rabbit |
| Applications: |
IHC/IP/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal antibody anti-Recombinant-CDKN1B is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM1W79 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
IHC: 1:50-1:100 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Function | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 1bCyclin-Dependent Kinase Inhibitor P27P27kip1 |
| Database Links | Reactome: R-MMU-187577Reactome: -MMU-198323Reactome: -MMU-2559582Reactome: -MMU-2559586Reactome: -MMU-6804116Reactome: -MMU-69202Reactome: -MMU-69231Reactome: -MMU-69563Reactome: -MMU-69656Reactome: -MMU-8849470Reactome: -MMU-9607240Reactome: -MMU-9634638 |
| Cellular Localisation | NucleusCytoplasmEndosomeNuclear And Cytoplasmic In Quiescent CellsAkt- Or Rsk-Mediated Phosphorylation On Thr-197Binds 14-3-3Translocates To The Cytoplasm And Promotes Cell Cycle ProgressionMitogen-Activated Uhmk1 Phosphorylation On Ser-10 Also Results In Translocation To The Cytoplasm And Cell Cycle ProgressionPhosphorylation On Ser-10 Facilitates Nuclear ExportTranslocates To The Nucleus On Phosphorylation Of Tyr-88 And Tyr-89Colocalizes At The Endosome With Snx6This Leads To Lysosomal Degradation |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 1b antibodyAnti-Cyclin-Dependent Kinase Inhibitor P27 antibodyAnti-P27kip1 antibodyAnti-Cdkn1b antibody |
Information sourced from Uniprot.org
