Host: | Rabbit |
Applications: | FC/IF/IHC/WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit monoclonal antibody anti-Recombinant-Sororin is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
Clonality : | Monoclonal |
Clone ID : | RM2P18 |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
Purification: | Protein A/G purified from cell culture supernatant |
Dilution Range: | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Gene Symbol: | CDCA5 |
Gene ID: | 113130 |
Uniprot ID: | CDCA5_HUMAN |
Function | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. |
Protein Name | SororinCell Division Cycle-Associated Protein 5P35 |
Database Links | Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2500257 |
Cellular Localisation | NucleusChromosomeCytoplasmAssociates With Nuclear Chromatin From S Phase Until Metaphase And Is Released In The Cytoplasm Upon Nuclear Envelope Breakdown |
Alternative Antibody Names | Anti-Sororin antibodyAnti-Cell Division Cycle-Associated Protein 5 antibodyAnti-P35 antibodyAnti-CDCA5 antibody |
Information sourced from Uniprot.org