| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Cell Division Control Protein 42 Homolog is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1Z88 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | WB: 1:500-1:1000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | CDC42 |
| Gene ID: | 998 |
| Uniprot ID: | CDC42_HUMAN |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation. |
| Protein Name | Cell Division Control Protein 42 HomologG25k Gtp-Binding Protein |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-182971Reactome: R-HSA-2029482Reactome: R-HSA-389359Reactome: R-HSA-3928662Reactome: R-HSA-418885Reactome: R-HSA-428543Reactome: R-HSA-4420097Reactome: R-HSA-525793Reactome: R-HSA-5625970Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5663213Reactome: R-HSA-5663220Reactome: R-HSA-5687128Reactome: R-HSA-8950505Reactome: R-HSA-8964616Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013423Reactome: R-HSA-9013424Reactome: R-HSA-9664422Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleMidbodyCell ProjectionDendriteLocalizes To Spindle During Prometaphase CellsMoves To The Central Spindle As Cells Progressed Through Anaphase To TelophaseLocalizes At The End Of Cytokinesis In The Intercellular Bridge Formed Between Two Daughter CellsIts Localization Is Regulated By The Activities Of Guanine Nucleotide Exchange Factor Ect2 And Gtpase Activating Protein Racgap1Colocalizes With Nek6 In The CentrosomeIn Its Active Gtp-Bound Form Localizes To The Leading Edge Membrane Of Migrating Dendritic Cells |
| Alternative Antibody Names | Anti-Cell Division Control Protein 42 Homolog antibodyAnti-G25k Gtp-Binding Protein antibodyAnti-CDC42 antibody |
Information sourced from Uniprot.org