Anti-Recombinant-CDC42 antibody [RM1Z88] (STJA0024963)

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STJA0024963
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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Cell Division Control Protein 42 Homolog is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1Z88
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CDC42
Gene ID: 998
Uniprot ID: CDC42_HUMAN
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation.
Protein Name Cell Division Control Protein 42 Homolog
G25k Gtp-Binding Protein
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-182971
Reactome: R-HSA-2029482
Reactome: R-HSA-389359
Reactome: R-HSA-3928662
Reactome: R-HSA-418885
Reactome: R-HSA-428543
Reactome: R-HSA-4420097
Reactome: R-HSA-525793
Reactome: R-HSA-5625970
Reactome: R-HSA-5626467
Reactome: R-HSA-5627123
Reactome: R-HSA-5663213
Reactome: R-HSA-5663220
Reactome: R-HSA-5687128
Reactome: R-HSA-8950505
Reactome: R-HSA-8964616
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013406
Reactome: R-HSA-9013408
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013423
Reactome: R-HSA-9013424
Reactome: R-HSA-9664422
Reactome: R-HSA-983231
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle
Midbody
Cell Projection
Dendrite
Localizes To Spindle During Prometaphase Cells
Moves To The Central Spindle As Cells Progressed Through Anaphase To Telophase
Localizes At The End Of Cytokinesis In The Intercellular Bridge Formed Between Two Daughter Cells
Its Localization Is Regulated By The Activities Of Guanine Nucleotide Exchange Factor Ect2 And Gtpase Activating Protein Racgap1
Colocalizes With Nek6 In The Centrosome
In Its Active Gtp-Bound Form Localizes To The Leading Edge Membrane Of Migrating Dendritic Cells
Alternative Antibody Names Anti-Cell Division Control Protein 42 Homolog antibody
Anti-G25k Gtp-Binding Protein antibody
Anti-CDC42 antibody

Information sourced from Uniprot.org