Anti-Recombinant-CD278/ICOS antibody [RM2L33] (STJA0025997)

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STJA0025997
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Host: Rabbit
Applications: FC/IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Inducible T-Cell Costimulator is suitable for use in Flow Cytometry, Immunofluorescence and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2L33
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: ICOS
Gene ID: 29851
Uniprot ID: ICOS_HUMAN
Post Translational Modifications N-glycosylated.
Function Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Acts also as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Protein Name Inducible T-Cell Costimulator
Activation-Inducible Lymphocyte Immunomediatory Molecule
Cd Antigen Cd278
Database Links Reactome: R-HSA-1257604 Q9Y6W8-1
Reactome: R-HSA-2219530 Q9Y6W8-1
Reactome: R-HSA-388841 Q9Y6W8-1
Reactome: R-HSA-6811558 Q9Y6W8-1
Reactome: R-HSA-9725371
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Antibody Names Anti-Inducible T-Cell Costimulator antibody
Anti-Activation-Inducible Lymphocyte Immunomediatory Molecule antibody
Anti-Cd Antigen Cd278 antibody
Anti-ICOS antibody
Anti-AILIM antibody

Information sourced from Uniprot.org