Anti-Recombinant-CD106/VCAM1 antibody [RM1RM11] (STJA0024094)

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STJA0024094
£309.50 - £472.50
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Host: Rabbit
Applications: IP/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-CD106/VCAM1 is suitable for use in Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1RM11
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IP: 1:20
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: Vcam1
Uniprot ID: VCAM1_MOUSE
Post Translational Modifications Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation.
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Protein Name Vascular Cell Adhesion Protein 1
V-Cam 1
Vcam-1
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1
Cellular Localisation Vascular Cell Adhesion Protein 1: Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Vascular Cell Adhesion Molecule-1: Secreted
Alternative Antibody Names Anti-Vascular Cell Adhesion Protein 1 antibody
Anti-V-Cam 1 antibody
Anti-Vcam-1 antibody
Anti-Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 antibody
Anti-Vcam1 antibody
Anti-Vcam-1 antibody

Information sourced from Uniprot.org