Anti-Recombinant-Cardiac Troponin I antibody [5F8] (STJA0002946)
SPECIFICATIONS
ClonalityMonoclonal
HostCHO cells
ConjugationUnconjugated
IsotypeIgG2 lambda
ImmunogenRecombinant human cardiac troponin complex protein produced by CHO-based proprietary suspension cell line.
General Information
| Short Description | Cho Cells monoclonal anti-Recombinant-Cardiac Troponin I for use in ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | CHO cells |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 5F8 |
| Isotype | IgG2 lambda |
| Conjugation | Unconjugated |
| Purification | MabSelect affinity chromatography following gel filtration |
| Formulation | 50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 (SPTN) |
| Storage Instruction | Store at-20 °C to-70 °C long term. Avoid multiple freeze-thaw cycles. |
| Dissociation Constant | 1.60 x 10-10 M (Troponin complex binding from solution) 1 x 10-12 M (Troponin complex binding from streptavidin surface) |
Target Information
| Immunogen | Recombinant human cardiac troponin complex protein produced by CHO-based proprietary suspension cell line. |
| Specificity | human cardiac troponin I |
Additional Info
| Background | Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it, myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle (Wikipedia) |
Information sourced from Uniprot.org