| Post Translational Modifications | Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization. |
| Function | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5. Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission. |
| Protein Name | Protein Bassoon |
| Cellular Localisation | CytoplasmPresynaptic Active ZoneCytoskeletonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePeripheral Membrane ProteinIn RetinaIs Localized In The Outer Plexiform Layer At Ribbon Synapses Formed By Rods And Cones But Was Absent From Basal Synaptic Contacts Formed By ConesIn The Retinal Inner Plexiform Layer Localized To Conventional Inhibitory Gabaergic SynapsesMade By Amacrine CellsBut Absent From The Bipolar Cell Ribbon Synapses |
| Alternative Antibody Names | Anti-Protein Bassoon antibodyAnti-Bsn antibody |
Information sourced from Uniprot.org
