Host: | Rabbit |
Applications: | IHC/IP/WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit monoclonal antibody anti-Recombinant-Beta-2-Microglobulin Cleaved Into-Beta-2-Microglobulin Form Pi 5.3 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality : | Monoclonal |
Clone ID : | RM2A17 |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.01M PBS |
Purification: | Protein A/G purified from cell culture supernatant |
Dilution Range: | IHC: 1:50-1:100 |
Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Gene Symbol: | B2M |
Gene ID: | 567 |
Uniprot ID: | B2MG_HUMAN |
Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation. |
Protein Name | Beta-2-Microglobulin Cleaved Into - Beta-2-Microglobulin Form Pi 5.3 |
Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1236977Reactome: R-HSA-164940Reactome: R-HSA-198933Reactome: R-HSA-2172127Reactome: R-HSA-2424491Reactome: R-HSA-6798695Reactome: R-HSA-877300Reactome: R-HSA-9637628Reactome: R-HSA-9705671Reactome: R-HSA-977225Reactome: R-HSA-983170 |
Cellular Localisation | SecretedCell SurfaceDetected In Serum And Urine(Microbial Infection) In The Presence Of MTuberculosis Esxa-Esxb Complex Decreased Amounts Of B2m Are Found On The Cell Surface |
Alternative Antibody Names | Anti-Beta-2-Microglobulin Cleaved Into - Beta-2-Microglobulin Form Pi 5.3 antibodyAnti-B2M antibodyAnti-CDABP0092 antibodyAnti-HDCMA22P antibody |
Information sourced from Uniprot.org