| Tissue Specificity | Cilium-specific protein. Expressed in neuroepithelial cells and developing radial glia of the developing cerebral cortex: present in both neuroepithelial and radial progenitor cells. In radial progenitors, found in the apical, cell soma domains of these cells (at protein level). Expressed in the primary cilia of postmitotic cortical neurons during embryonic and postnatal development. |
| Post Translational Modifications | Sumoylation is required for PKD2 entry into cilium. |
| Function | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it.the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. May regulate ARF6- and RAB22A-dependent endocytic recycling traffic. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 13bAdp-Ribosylation Factor-Like Protein 2-Like 1Arl2-Like Protein 1Protein Hennin |
| Database Links | Reactome: R-MMU-5624958Reactome: -MMU-9013406Reactome: -MMU-9646399 |
| Cellular Localisation | Cell ProjectionCilium MembraneLipid-AnchorCiliumAssociates With The Cilium Membrane Via PalmitoylationLocalizes To Proximal Ciliary MembranesTo An Inversin-Like Subciliary Membrane CompartmentExcluding The Transition Zone |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 13b antibodyAnti-Adp-Ribosylation Factor-Like Protein 2-Like 1 antibodyAnti-Arl2-Like Protein 1 antibodyAnti-Protein Hennin antibodyAnti-Arl13b antibodyAnti-Arl2l1 antibody |
Information sourced from Uniprot.org
