Anti-Recombinant-160 kDa Neurofilament Medium antibody [SM0702] (STJA0010702)

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STJA0010702

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Host: Mouse
Applications: WB/IHC/IF
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Recombinant-160 kDa Neurofilament Medium is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: SM0702
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol.
Purification: Affinity purification
Dilution Range: WB (M, R) 1:500-1:2000
IHC/IF (H, M, R, Mk) 1:500-1:1000
Storage Instruction: Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol: Nefm
Gene ID: 18040
Uniprot ID: NFM_MOUSE
Immunogen: Recombinant protein corresponding to Mouse 160 kDa Neurofilament Medium
Post Translational Modifications There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Function Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Protein Name Neurofilament Medium Polypeptide
Nf-M
160 Kda Neurofilament Protein
Neurofilament 3
Neurofilament Triplet M Protein
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Axon
Alternative Antibody Names Anti-Neurofilament Medium Polypeptide antibody
Anti-Nf-M antibody
Anti-160 Kda Neurofilament Protein antibody
Anti-Neurofilament 3 antibody
Anti-Neurofilament Triplet M Protein antibody
Anti-Nefm antibody
Anti-Nef3 antibody
Anti-Nfm antibody

Information sourced from Uniprot.org

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