| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RDX |
| Gene ID: | 5962 |
| Uniprot ID: | RADI_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Radixin (NP_002897.1). |
| Immunogen Sequence: | MPKPINVRVTTMDAELEFAI QPNTTGKQLFDQVVKTVGLR EVWFFGLQYVDSKGYSTWLK LNKKVTQQDVKKENPLQFKF RAKFFPEDVSEELIQEITQR LFFLQVKEAILNDEIYCPPE TAVLLASYAVQAKYGDYNKE IHKPGYLANDRLLPQRVLEQ HKLTKEQWEERIQNWHEEHR GMLREDSMMEYLKIAQDLEM |
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. |
| Function | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| Protein Name | Radixin |
| Database Links | Reactome: R-HSA-437239Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCleavage FurrowCell ProjectionMicrovillusStereociliumEnriched At The Stereocilium Base With Very Low Levels In The Shaft Of Stereociliary BundlesHighly Concentrated In The Undercoat Of The Cell-To-Cell Adherens Junction And The Cleavage Furrow In The Interphase And Mitotic PhaseRespectively |
| Alternative Antibody Names | Anti-Radixin antibodyAnti-RDX antibody |
Information sourced from Uniprot.org