• Western blot analysis of lysates from AD293 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-RD3 antibody (126-176 aa) (STJ196042)

SKU:
STJ196042

Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein RD3 (126-176 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RD3
Gene ID: 343035
Uniprot ID: RD3_HUMAN
Immunogen Region: 126-176 aa
Specificity: This antibody detects endogenous levels of RD3 at Human/Mouse
Immunogen: Synthesized peptide derived from the human RD3 at the amino acid range 126-176
Function Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
Protein Name Protein Rd3
Retinal Degeneration Protein 3
Cellular Localisation Cell Projection
Cilium
Photoreceptor Outer Segment
Photoreceptor Inner Segment
Endosome
Nucleus
Cytoplasm
Perinuclear Region
Colocalizes With Gucy2e And Gucy2f In Rods And Cones Photoreceptors
Colocalizes With Guk1 In Photoreceptor Inner Segments And To A Lesser Extent In The Outer Plexiform Layer
Strong Dot-Like Perinuclear Staining In The Epithelial Cells
Alternative Antibody Names Anti-Protein Rd3 antibody
Anti-Retinal Degeneration Protein 3 antibody
Anti-RD3 antibody
Anti-C1orf36 antibody

Information sourced from Uniprot.org

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