| Post Translational Modifications | Phosphorylated at Ser-136 by MAPK14/p38-alpha-activated MAPKAPK2/MK2.this phosphorylation is stress-dependent.this phosphorylation decreases its RNA-binding capacity therefore affecting RNA nuclear exosome-mediated degradation. This phosphorylation mediates YWHAE and YWHAZ interactions. |
| Function | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability. |
| Protein Name | Rna-Binding Protein 7Rna-Binding Motif Protein 7 |
| Database Links | Reactome: R-MMU-72163 |
| Cellular Localisation | NucleusNucleoplasmExcluded From The Nucleolus |
| Alternative Antibody Names | Anti-Rna-Binding Protein 7 antibodyAnti-Rna-Binding Motif Protein 7 antibodyAnti-Rbm7 antibody |
Information sourced from Uniprot.org
