| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNA-binding protein 25 (763-813 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBM25 |
| Gene ID: |
58517 |
| Uniprot ID: |
RBM25_HUMAN |
| Immunogen Region: |
763-813 aa |
| Specificity: |
This antibody detects endogenous levels of RBM25 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human RBM25 at the amino acid range 763-813 |
| Function | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. |
| Protein Name | Rna-Binding Protein 25Arg/Glu/Asp-Rich Protein Of 120 KdaRed120Protein S164Rna-Binding Motif Protein 25Rna-Binding Region-Containing Protein 7 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleCytoplasmColocalizes PredominantlyWith Sfrs2 And Luc7l3 Splicing FactorsIn Nuclear SpecklesCytoplasmic Localization Is Faint |
| Alternative Antibody Names | Anti-Rna-Binding Protein 25 antibodyAnti-Arg/Glu/Asp-Rich Protein Of 120 Kda antibodyAnti-Red120 antibodyAnti-Protein S164 antibodyAnti-Rna-Binding Motif Protein 25 antibodyAnti-Rna-Binding Region-Containing Protein 7 antibodyAnti-RBM25 antibodyAnti-RNPC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
