| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-RBBP7 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 3A12 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: | Affinity Purified |
| Concentration: | 0.85 mg/mL |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | RBBP7 |
| Gene ID: | 5931 |
| Uniprot ID: | RBBP7_HUMAN |
| Immunogen: | Full length human recombinant protein of human RBBP7 produced in 293T cell. |
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication.the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling.and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development.and the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp7Histone Acetyltransferase Type B Subunit 2Nucleosome-Remodeling Factor Subunit Rbap46Retinoblastoma-Binding Protein 7Rbbp-7Retinoblastoma-Binding Protein P46 |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8951664Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp7 antibodyAnti-Histone Acetyltransferase Type B Subunit 2 antibodyAnti-Nucleosome-Remodeling Factor Subunit Rbap46 antibodyAnti-Retinoblastoma-Binding Protein 7 antibodyAnti-Rbbp-7 antibodyAnti-Retinoblastoma-Binding Protein P46 antibodyAnti-RBBP7 antibodyAnti-RBAP46 antibody |
Information sourced from Uniprot.org
