Anti-RBBP6 antibody (270-350 aa) (STJ191314)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 270-350
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RBBP6 (270-350 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBBP6 |
| Gene ID | 5930 |
| Uniprot ID | RBBP6_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Immunogen Region | 270-350 aa |
| Specificity | RBBP6 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53.may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. (Microbial infection) Isoform 1: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rbbp6Proliferation Potential-Related ProteinProtein P2p-RRing-Type E3 Ubiquitin Transferase Rbbp6Retinoblastoma-Binding Q Protein 1Rbq-1Retinoblastoma-Binding Protein 6P53-Associated Cellular Protein Of Testis |
| Database Links | Reactome: R-HSA-9013422Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleolusChromosomeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Mitotic ChromosomesColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rbbp6 antibodyAnti-Proliferation Potential-Related Protein antibodyAnti-Protein P2p-R antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rbbp6 antibodyAnti-Retinoblastoma-Binding Q Protein 1 antibodyAnti-Rbq-1 antibodyAnti-Retinoblastoma-Binding Protein 6 antibodyAnti-P53-Associated Cellular Protein Of Testis antibodyAnti-RBBP6 antibodyAnti-P2PR antibodyAnti-PACT antibodyAnti-RBQ1 antibodyAnti-My038 antibody |
Information sourced from Uniprot.org