| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RB1CC1 |
| Gene ID: |
9821 |
| Uniprot ID: |
RBCC1_HUMAN |
| Immunogen Region: |
1280-1400 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1280-1400 of human FIP200 (NP_055596.3). |
| Immunogen Sequence: |
TRGDSSSLVAELQEKLQEEK AKFLEQLEEQEKRKNEEMQN VRTSLIAEQQTNFNTVLTRE KMRKENIINDLSDKLKSTMQ QQERDKDLIESLSEDRARLL EEKKKLEEEVSKLRSSSFVP S |
| Tissue Specificity | Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. |
| Post Translational Modifications | Phosphorylation at Ser-734 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. |
| Function | Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. |
| Protein Name | Rb1-Inducible Coiled-Coil Protein 1Fak Family Kinase-Interacting Protein Of 200 KdaFip200 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | NucleusCytoplasmCytosolPreautophagosomal StructureLysosomeUnder Starvation ConditionsIs Localized To Puncate Structures Primarily Representing The Isolation Membrane That Sequesters A Portion Of The Cytoplasm Resulting In The Formation Of An Autophagosome |
| Alternative Antibody Names | Anti-Rb1-Inducible Coiled-Coil Protein 1 antibodyAnti-Fak Family Kinase-Interacting Protein Of 200 Kda antibodyAnti-Fip200 antibodyAnti-RB1CC1 antibodyAnti-KIAA0203 antibodyAnti-RBICC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
