Anti-RASSF7/HRAS1 antibody (Internal) (STJ71489)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RASSF7/HRAS1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 37kDa band observed in lysates of cell line Jurkat (calculated MW of 39.9kDa according to NP_003466.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | RASSF7 |
| Gene ID | 8045 |
| Uniprot ID | RASF7_HUMAN |
| Accession Number | NP_003466.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | CTDLRGLELRVQRN |
Additional Info
| Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
| Protein Name | Ras Association Domain-Containing Protein 7Hras1-Related Cluster Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Gamma-Tubulin |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 7 antibodyAnti-Hras1-Related Cluster Protein 1 antibodyAnti-RASSF7 antibodyAnti-C11orf13 antibodyAnti-HRC1 antibody |
Information sourced from Uniprot.org