Anti-RASSF6 antibody (1-303) (STJ27165)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RASSF6 (1-303) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASSF6 |
| Gene ID | 166824 |
| Uniprot ID | RASF6_HUMAN |
| Immunogen Region | 1-303 |
| Immunogen Sequence | MTMMAHQYPSWIFINEKTFI TREQLNSLLKTYNIFYENQK NLHILYGETEDGKLIVEGML DIFWGVKRPIQLKIQDEKPF SSFTSMKSSDVFSSKGMTRW GEFDDLYRISELDRTQIPMS EKRNSQEDYLSYHSNTLKPH AKDEPDSPVLYRTMSEAALV RKRMKPLMMDRKERQKNRAS INGHFYNHEIENSPQDFALH IIFATGEQRRLKKTDIPLLQ RLLQGPSEKNARIFLMDKD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human RASSF6 (NP_001257320.1). |
Additional Info
| Tissue Specificity | Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart. |
| Function | Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B. |
| Protein Name | Ras Association Domain-Containing Protein 6 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 6 antibodyAnti-RASSF6 antibody |
Information sourced from Uniprot.org