| Tissue Specificity | Highly expressed in heart. Detected at lower levels in placenta and pancreas. |
| Function | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. |
| Protein Name | Ras-Interacting Protein 1Rain |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusGolgi StackAssociated With Perinuclear VesiclesIs Recruited To Golgi Stacks By Activated Hras |
| Alternative Antibody Names | Anti-Ras-Interacting Protein 1 antibodyAnti-Rain antibodyAnti-RASIP1 antibody |
Information sourced from Uniprot.org
