Anti-RASA1 antibody (200-300) [S5700RM] (STJ11105700)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Ras Gtpase-Activating Protein 1 (200-300) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5700RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASA1 |
| Gene ID | 5921 |
| Uniprot ID | RASA1_HUMAN |
| Immunogen Region | 200-300 |
| Immunogen Sequence | KSGSYLIRESDRRPGSFVLS FLSQMNVVNHFRIIAMCGDY YIGGRRFSSLSDLIGYYSHV SCLLKGEKLLYPVAPPEPVE DRRRVRAILPYTKVPDTDEI S |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human RASA1 (P20936). |
Additional Info
| Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). |
| Post Translational Modifications | The N-terminus is blocked. Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity. |
| Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.this stimulation may be further increased in the presence of NCK1. |
| Protein Name | Ras Gtpase-Activating Protein 1GapGtpase-Activating ProteinRasgapRas P21 Protein ActivatorP120gap |
| Database Links | Reactome: R-HSA-186763Reactome: R-HSA-3928662Reactome: R-HSA-5218921Reactome: R-HSA-5658442Reactome: R-HSA-8849471 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein 1 antibodyAnti-Gap antibodyAnti-Gtpase-Activating Protein antibodyAnti-Rasgap antibodyAnti-Ras P21 Protein Activator antibodyAnti-P120gap antibodyAnti-RASA1 antibodyAnti-GAP antibodyAnti-RASA antibody |
Information sourced from Uniprot.org