Name: Anti-Ras antibody (1-186aa) [AT2F8] (STJA0041727)
SKU: STJA0041727
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	Mouse
Applications:	ELISA/WB/ICC/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Mouse monoclonal anti-Ras (1-186aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.

Clonality :	Monoclonal
Clone ID :	AT2F8
Conjugation:	Unconjugated
Isotype:	IgG2bk
Formulation:	Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purification:	By protein-A affinity chromatography
Concentration:	1 mg/mL
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	KRAS
Gene ID:	3845
Uniprot ID:	RASK_HUMAN
Immunogen Region:	1-186aa
Accession Number:	NP_203524
Immunogen:	Recombinant human KRAS (1-186aa) purified from E. coli

Post Translational Modifications	Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Palmitoylated at Lys-182, Lys-184 and Lys-185. Palmitoylation on lysine residues is promoted by palmitoylation at Cys-180. Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways. Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Protein Name	Gtpase Kras K-Ras 2 Ki-Ras C-K-Ras C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-4086398 P01116-2 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-8951936 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9674555 Reactome: R-HSA-9680350 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Endomembrane System Cytoplasm Cytosol Isoform 2b: Cell Membrane
Alternative Antibody Names	Anti-Gtpase Kras antibody Anti-K-Ras 2 antibody Anti-Ki-Ras antibody Anti-C-K-Ras antibody Anti-C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed antibody Anti-KRAS antibody Anti-KRAS2 antibody Anti-RASK2 antibody

Information sourced from Uniprot.org

Model	Name	Host	Clonality	Reactivity	Application
STJA0041606	Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041606)	Mouse	Monoclonal	Human	ELISA/WB/ICC/IF/FACS
STJA0041946	Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041946)	Mouse	Monoclonal	Human	ELISA/WB/FACS
STJA0033669	Anti-Ras-A146V Mutant antibody (STJA0033669)	Mouse	Monoclonal	Vertebrates	WB/IHC-P/ELISA
STJA0033659	Anti-Ras-G12S Mutant antibody (STJA0033659)	Mouse	Monoclonal	Vertebrates	WB/ICC/IF/ELISA
STJA0033657	Anti-Ras-G13D Mutant antibody (STJA0033657)	Mouse	Monoclonal	Vertebrates	WB/IHC-P/ICC/IF/ELISA

Anti-Ras antibody (1-186aa) [AT2F8] (STJA0041727)

General Information

Product Properties

Target Information

Additional Info

Product Review

Related Products

Related Products

Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041606)

Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041946)

Anti-Ras-A146V Mutant antibody (STJA0033669)

Anti-Ras-G12S Mutant antibody (STJA0033659)

Anti-Ras-G13D Mutant antibody (STJA0033657)