Anti-RAP2B antibody (98-147 aa) (STJ95368)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAP2B at the amino acid range 98-147
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rap-2b (98-147 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAP2B |
| Gene ID | 5912 |
| Uniprot ID | RAP2B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAP2B at the amino acid range 98-147 |
| Immunogen Region | 98-147 aa |
| Specificity | Rap 2B Polyclonal Antibody detects endogenous levels of Rap 2B protein. |
Additional Info
| Post Translational Modifications | Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK. |
| Function | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. |
| Protein Name | Ras-Related Protein Rap-2b |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideAssociated With Red Blood Cells-Released Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-2b antibodyAnti-RAP2B antibody |
Information sourced from Uniprot.org