| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ras-related protein Rap-2b (98-147 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP2B |
| Gene ID: | 5912 |
| Uniprot ID: | RAP2B_HUMAN |
| Immunogen Region: | 98-147 aa |
| Specificity: | Rap 2B Polyclonal Antibody detects endogenous levels of Rap 2B protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RAP2B at the amino acid range 98-147 |
| Post Translational Modifications | Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK. |
| Function | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. |
| Protein Name | Ras-Related Protein Rap-2b |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Recycling Endosome Membrane Lipid-Anchor Cytoplasmic Side Associated With Red Blood Cells-Released Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-2b antibody Anti-RAP2B antibody |
Information sourced from Uniprot.org