| Function | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. |
| Protein Name | Ras-Related Protein Rap-2aRbbp-30 |
| Database Links | |
| Cellular Localisation | MidbodyCell ProjectionLamellipodium MembraneGolgi ApparatusRecycling Endosome MembraneLipid-AnchorCytoplasmic SideLysosomeLocalized To The GolgiMay Also Localize To The Gelatinase-Containing Granules Of NeutrophilsColocalized With Rasgef1b To Midbody At TelophaseLocalized Predominantly To The Plasma MembraneWhere It Is Enriched At Lamellipodia RufflesCycles Between The Lamellipodia Plasma Membrane And Endosomes When Ubiquitinated By The Ecs(Rab40b) ComplexWithout The Ubiquitin SignalSorted To Lysosomes For Degradation |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-2a antibodyAnti-Rbbp-30 antibodyAnti-RAP2A antibody |
Information sourced from Uniprot.org
