• Western blot analysis of various lysates using RanBP9 Rabbit polyclonal antibody (STJ113992) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-RANBP9 antibody (480-605) (STJ113992)

SKU:
STJ113992

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RANBP9 (480-605) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RANBP9
Gene ID: 10048
Uniprot ID: RANB9_HUMAN
Immunogen Region: 480-605
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 480-605 of human RanBP9 (NP_005484.2).
Immunogen Sequence: PFSSPSMSPSHGMNIHNLAS GKGSTAHFSGFESCSNGVIS NKAHQSYCHSNKHQSSNLNV PELNSINMSRSQQVNNFTSN DVDMETDHYSNGVGETSSNG FLNGSSKHDHEMEDCDTEME VDSSQL
Tissue Specificity Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.
Post Translational Modifications Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C). Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.
Function May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Protein Name Ran-Binding Protein 9
Ranbp9
Bpm-L
Bpm90
Ran-Binding Protein M
Ranbpm
Ranbp7
Database Links Reactome: R-HSA-373760
Reactome: R-HSA-5673001
Reactome: R-HSA-8851805
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
The Unphosphorylated Form Is Predominantly Cytoplasmic
A Phosphorylated Form Is Associated With The Plasma Membrane
Alternative Antibody Names Anti-Ran-Binding Protein 9 antibody
Anti-Ranbp9 antibody
Anti-Bpm-L antibody
Anti-Bpm90 antibody
Anti-Ran-Binding Protein M antibody
Anti-Ranbpm antibody
Anti-Ranbp7 antibody
Anti-RANBP9 antibody
Anti-RANBPM antibody

Information sourced from Uniprot.org

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