• Immunocytochemistry stain of Hela using RanBP9 mouse mAb (1:300).
  • Immunoprecipitation analysis of Hela cell lysates using RanBP9 mouse mAb.
  • Western blot detection of RanBP9 in Jurkat, MOLT-4 and CEM cell lysates and using RanBP9 mouse mAb (1:1000 diluted).Predicted band size: 78KDa.Observed band size: 95KDa.

Anti-RANBP9 antibody [3C3-E11-C12] (STJ99126)

SKU:
STJ99126

Current Stock:
Host: Mouse
Applications: WB/ICC/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Ran-binding protein 9 is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: 3C3-E11-C12
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000
ICC 1:300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RANBP9
Gene ID: 10048
Uniprot ID: RANB9_HUMAN
Specificity: This antibody detects endogenous levels of RanBP9 and does not cross-react with related proteins.
Immunogen: Purified recombinant human RanBP9 protein fragments expressed in E.coli.
Post Translational Modifications Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C). Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.
Function May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Protein Name Ran-Binding Protein 9
Ranbp9
Bpm-L
Bpm90
Ran-Binding Protein M
Ranbpm
Ranbp7
Database Links Reactome: R-HSA-373760
Reactome: R-HSA-5673001
Reactome: R-HSA-8851805
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
The Unphosphorylated Form Is Predominantly Cytoplasmic
A Phosphorylated Form Is Associated With The Plasma Membrane
Alternative Antibody Names Anti-Ran-Binding Protein 9 antibody
Anti-Ranbp9 antibody
Anti-Bpm-L antibody
Anti-Bpm90 antibody
Anti-Ran-Binding Protein M antibody
Anti-Ranbpm antibody
Anti-Ranbp7 antibody
Anti-RANBP9 antibody
Anti-RANBPM antibody

Information sourced from Uniprot.org

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