Anti-RANBP3 antibody [R97-2F-2] (STJA0035497)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from RANBP3
General Information
| Short Description | Rabbit monoclonal anti-RANBP3 for use in WB, IHC-P, ICC, IF, IP and FC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R97-2F-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IF 1:50-1:200IP 1:50FC 1:50 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RANBP3 |
| Gene ID | 8498 |
| Uniprot ID | RANB3_HUMAN |
| Immunogen | A synthesized peptide derived from RANBP3 |
Additional Info
| Tissue Specificity | Widely expressed with high levels in testis and heart. |
| Post Translational Modifications | Phosphorylation at Ser-126 promotes its import into the nucleus. |
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Protein Name | Ran-Binding Protein 3Ranbp3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNuclear Import Is Promoted By Phosphorylation At Ser-126 And Is Dependent On Kpna4 |
| Alternative Antibody Names | Anti-Ran-Binding Protein 3 antibodyAnti-Ranbp3 antibodyAnti-RANBP3 antibody |
Information sourced from Uniprot.org