| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-E3 SUMO-protein ligase RanBP2 (108-158 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RANBP2 |
| Gene ID: | 5903 |
| Uniprot ID: | RBP2_HUMAN |
| Immunogen Region: | 108-158 aa |
| Specificity: | This antibody detects endogenous levels of RBP2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human RBP2 at the amino acid range 108-158 |
| Function | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. |
| Protein Name | E3 Sumo-Protein Ligase Ranbp2358 Kda NucleoporinNuclear Pore Complex Protein Nup358Nucleoporin Nup358Ran-Binding Protein 2Ranbp2P270 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-141444Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-5663220Reactome: R-HSA-6784531Reactome: R-HSA-68877Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9648025Reactome: R-HSA-9705671Reactome: R-HSA-9725370 |
| Cellular Localisation | NucleusNucleus MembraneNuclear Pore ComplexNucleus EnvelopeDetected In Diffuse And Discrete Intranuclear FociCytoplasmic Filaments |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Ranbp2 antibodyAnti-358 Kda Nucleoporin antibodyAnti-Nuclear Pore Complex Protein Nup358 antibodyAnti-Nucleoporin Nup358 antibodyAnti-Ran-Binding Protein 2 antibodyAnti-Ranbp2 antibodyAnti-P270 antibodyAnti-RANBP2 antibodyAnti-NUP358 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
