Anti-Rad51D antibody (1-328) (STJ29672)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Rad51D (1-328) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAD51D |
| Gene ID | 5892 |
| Uniprot ID | RA51D_HUMAN |
| Immunogen Region | 1-328 |
| Immunogen Sequence | MGVLRVGLCPGLTEEMIQLL RSHRIKTVVDLVSADLEEVA QKCGLSYKALVALRRVLLAQ FSAFPVNGADLYEELKTSTA ILSTGIGSLDKLLDAGLYTG EVTEIVGGPGSGKTQVCLCM AANVAHGLQQNVLYVDSNGG LTASRLLQLLQAKTQDEEEQ AEALRRIQVVHAFDIFQMLD VLQELRGTVAQQVTGSSGTV KVVVVDSVTAVVSPLLGGQQ REGLALMMQLARELKTLAR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human Rad51D (NP_002869.3). |
Additional Info
| Tissue Specificity | Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes. |
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. |
| Protein Name | Dna Repair Protein Rad51 Homolog 4R51h3Rad51 Homolog DRad51-Like Protein 3Trad |
| Database Links | Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693616Reactome: R-HSA-6796648Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeTelomere |
| Alternative Antibody Names | Anti-Dna Repair Protein Rad51 Homolog 4 antibodyAnti-R51h3 antibodyAnti-Rad51 Homolog D antibodyAnti-Rad51-Like Protein 3 antibodyAnti-Trad antibodyAnti-RAD51D antibodyAnti-RAD51L3 antibody |
Information sourced from Uniprot.org