| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ras-related protein Rab-6A (113-162 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB6A |
| Gene ID: | 5870 |
| Uniprot ID: | RAB6A_HUMAN |
| Immunogen Region: | 113-162 aa |
| Specificity: | Rab 6A Polyclonal Antibody detects endogenous levels of Rab 6A protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RAB6A at the amino acid range 113-162 |
| Post Translational Modifications | Prenylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development (Probable). |
| Protein Name | Ras-Related Protein Rab-6aRab-6 |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-6811440Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic VesicleSecretory VesicleAcrosome MembranePeripheral Membrane ProteinBicd2 Facilitates Its Targeting To Golgi Apparatus MembraneIsoform 1: Golgi Apparatus MembraneIsoform 2: Golgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-6a antibodyAnti-Rab-6 antibodyAnti-RAB6A antibodyAnti-RAB6 antibody |
Information sourced from Uniprot.org
