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Anti-RAB5A antibody (71-120 aa) (STJ96821)

Western blot analysis of lysate from HeLa cells, using RAB5A Antibody.
Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Western blot analysis of HeLa cells using Rab 5A Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-RAB5A antibody (71-120 aa) (STJ96821)

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STJ96821

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Ras-related protein Rab-5A (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	RAB5A
Gene ID:	5868
Uniprot ID:	RAB5A_HUMAN
Immunogen Region:	71-120 aa
Specificity:	Rab 5A Polyclonal Antibody detects endogenous levels of Rab 5A protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the Internal region of human RAB5A at the amino acid range 71-120

Function	Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
Protein Name	Ras-Related Protein Rab-5a
Database Links	Reactome: R-HSA-1660499 Reactome: R-HSA-8854214 Reactome: R-HSA-8856828 Reactome: R-HSA-8873719 Reactome: R-HSA-8876198 Reactome: R-HSA-9636383 Reactome: R-HSA-983231
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Early Endosome Membrane Melanosome Cytoplasmic Vesicle Cell Projection Ruffle Membrane Cytoplasm Cytosol Phagosome Membrane Endosome Membrane Enriched In Stage I Melanosomes Alternates Between Membrane-Bound And Cytosolic Forms (Probable)
Alternative Antibody Names	Anti-Ras-Related Protein Rab-5a antibody Anti-RAB5A antibody Anti-RAB5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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