Host: | Rabbit |
Applications: | IHC/WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-RAB4A (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Lyophilised |
Purification: | IgG purified |
Dilution Range: | IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Gene Symbol: | RAB4A |
Gene ID: | 5867 |
Uniprot ID: | RAB4A_HUMAN |
Immunogen Region: | C-Term |
Specificity: | Specific for RAB4A. |
Immunogen: | A synthetic peptide from c-terminal region of human Ras-related protein Rab-4A (RAB4A) conjugated to an immunogenic carrier protein has been used as the antigen. |
Function | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
Protein Name | Ras-Related Protein Rab-4a |
Database Links | Reactome: R-HSA-1445148 Reactome: R-HSA-1660499 Reactome: R-HSA-8854214 Reactome: R-HSA-8873719 Reactome: R-HSA-8875656 |
Cellular Localisation | Membrane Peripheral Membrane Protein Cytoplasm Early Endosome Membrane Recycling Endosome Membrane Generally Associated With Membranes Cytoplasmic When Phosphorylated By Cdk1 |
Alternative Antibody Names | Anti-Ras-Related Protein Rab-4a antibody Anti-RAB4A antibody Anti-RAB4 antibody |
Information sourced from Uniprot.org