| Host: | Goat |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal RA4, member RAS oncogene family (105aa C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet include |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: | This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: | 3 mg/mL |
| Dilution Range: | WB 1:250-1:2000 |
| Storage Instruction: | For continuous use, store at 2-8 deg;C for one-two days. For extended storage, store in-20 deg;C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: | RAB4A |
| Gene ID: | 5867 |
| Uniprot ID: | RAB4A_HUMAN |
| Immunogen Region: | 105aa C-Term |
| Accession Number: | ENSG00000168118 |
| Specificity: | In cell lysates and transfected cells detects Rab4 by Western blot. |
| Immunogen: | Purified recombinant peptide derived from within residues 105 aa to the C-terminus of Rab4a produced in E. coli. |
| Post Translational Modifications | Phosphorylated by CDK1 kinase during mitosis. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4a |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-1660499Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8875656 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmEarly Endosome MembraneRecycling Endosome MembraneGenerally Associated With MembranesCytoplasmic When Phosphorylated By Cdk1 |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-4a antibodyAnti-RAB4A antibodyAnti-RAB4 antibody |
Information sourced from Uniprot.org
