| Host: | Goat |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse/Monkey/Canine |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-RA4, member RAS oncogene family (105aa C-Term) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: | This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: | 3 mg/mL |
| Dilution Range: | WB 1:250-1:2000 |
| Storage Instruction: | For continuous use, store at 2-8 deg;C for one-two days. For extended storage, store in-20 deg;C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: | RAB4A |
| Gene ID: | 5867 |
| Uniprot ID: | RAB4A_HUMAN |
| Immunogen Region: | 105aa C-Term |
| Accession Number: | ENSG00000168118 |
| Specificity: | In cell lysates and transfected cells detects Rab4 by Western blot. |
| Immunogen: | Purified recombinant peptide derived from within residues 105 aa to the C-terminus of Rab4a produced in E. coli. |
| Post Translational Modifications | Phosphorylated by CDK1 kinase during mitosis. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. |
| Function | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4a |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-1660499Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8875656 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmEarly Endosome MembraneRecycling Endosome MembraneGenerally Associated With MembranesCytoplasmic When Phosphorylated By Cdk1 |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-4a antibodyAnti-RAB4A antibodyAnti-RAB4 antibody |
Information sourced from Uniprot.org
