| Post Translational Modifications | Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes.the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. |
| Protein Name | Ras-Related Protein Rab-38Melanoma Antigen Ny-Mel-1 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideMelanosomeCytoplasmic VesiclePhagosomePhagosome MembraneMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-38 antibodyAnti-Melanoma Antigen Ny-Mel-1 antibodyAnti-RAB38 antibody |
Information sourced from Uniprot.org
