Anti-RAB33B antibody (100-180 aa) (STJ191281)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 100-180
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-33B (100-180 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB33B |
| Gene ID | 83452 |
| Uniprot ID | RB33B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 100-180 |
| Immunogen Region | 100-180 aa |
| Specificity | RB33B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner. |
| Protein Name | Ras-Related Protein Rab-33b |
| Database Links | Reactome: R-HSA-6811438Reactome: R-HSA-8854214Reactome: R-HSA-8873719 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorGolgi ApparatusCis-Golgi NetworkPreautophagosomal Structure MembraneUnder Starvation Conditions Punctate Rab33b-Positive Structures Are Often Observed In The CytoplasmUnder Starved Conditions Rab33b Translocates From The Golgi To PhagophoresThis Translocation Is Driven By Interaction With Atg16l1 |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-33b antibodyAnti-RAB33B antibody |
Information sourced from Uniprot.org