| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Ras-related protein Rab-31 (50-130 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB31 |
| Gene ID: | 11031 |
| Uniprot ID: | RAB31_HUMAN |
| Immunogen Region: | 50-130 aa |
| Specificity: | Rab 31 Polyclonal Antibody detects endogenous levels of Rab 31 protein. |
| Immunogen: | Synthesized peptide derived from Rab 31 at the amino acid range 50-130 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. |
| Protein Name | Ras-Related Protein Rab-31 Ras-Related Protein Rab-22b |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-8873719 Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Trans-Golgi Network Membrane Lipid-Anchor Cytoplasmic Side Early Endosome Cytoplasmic Vesicle Phagosome Phagosome Membrane Rapidly Recruited To Phagosomes Containing S Aureus Or M Tuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-31 antibody Anti-Ras-Related Protein Rab-22b antibody Anti-RAB31 antibody Anti-RAB22B antibody |
Information sourced from Uniprot.org
