| Post Translational Modifications | In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells. |
| Function | The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. |
| Protein Name | Ras-Related Protein Rab-7l1Rab-7-Like Protein 1Ras-Related Protein Rab-29 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmPerinuclear RegionGolgi ApparatusGolgi Apparatus MembraneTrans-Golgi NetworkVacuoleCytoskeletonColocalizes With Lrrk2 Along Tubular Structures Emerging From Golgi ApparatusColocalizes With Gm130 At The Golgi ApparatusColocalizes With Dynamic Tubules Emerging From And Retracting To The Golgi ApparatusColocalizes With Tgn46 At The Trans-Golgi Network (Tgn)In Salmonella Enterica Serovar Typhi (STyphi) Infected Epithelial CellsIs Recruited And Colocalized With Both STyphi-Containing Vacuoles And Dynamic Tubules As Well As Those Emerging From The Vacuole Toward The Cell Periphery |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-7l1 antibodyAnti-Rab-7-Like Protein 1 antibodyAnti-Ras-Related Protein Rab-29 antibodyAnti-RAB29 antibodyAnti-RAB7L1 antibody |
Information sourced from Uniprot.org
