• Western blot analysis of lysates from HT-29 cells, using RAB7L1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HepG2 cells using RAB7L1 antibody.
  • Western blot analysis of various cells using Rab 7L1 Polyclonal Antibody

Anti-RAB29 antibody (115-164 aa) (STJ95304)

SKU:
STJ95304

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ras-related protein Rab-7L1 (115-164 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAB29
Gene ID: 8934
Uniprot ID: RAB7L_HUMAN
Immunogen Region: 115-164 aa
Specificity: Rab 7L1 Polyclonal Antibody detects endogenous levels of Rab 7L1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RAB7L1 at the amino acid range 115-164
Post Translational Modifications In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells.
Function The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
Protein Name Ras-Related Protein Rab-7l1
Rab-7-Like Protein 1
Ras-Related Protein Rab-29
Database Links Reactome: R-HSA-8873719
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Cytoplasm
Perinuclear Region
Golgi Apparatus
Trans-Golgi Network
Vacuole
Cytoskeleton
Colocalizes With Lrrk2 Along Tubular Structures Emerging From Golgi Apparatus
Colocalizes With Gm130 At The Golgi Apparatus
Colocalizes With Dynamic Tubules Emerging From And Retracting To The Golgi Apparatus
Colocalizes With Tgn46 At The Trans-Golgi Network (Tgn)
In Salmonella Enterica Serovar Typhi (S
Typhi) Infected Epithelial Cells
Is Recruited And Colocalized With Both S
Typhi-Containing Vacuoles And Dynamic Tubules As Well As Those Emerging From The Vacuole Toward The Cell Periphery
Alternative Antibody Names Anti-Ras-Related Protein Rab-7l1 antibody
Anti-Rab-7-Like Protein 1 antibody
Anti-Ras-Related Protein Rab-29 antibody
Anti-RAB29 antibody
Anti-RAB7L1 antibody

Information sourced from Uniprot.org

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