| Tissue Specificity | Isoform S: Isoform S is detected in most tissues investigated: cortex, liver, kidney, skeletal muscle, adipose tissue, testis, urothelium, lung, bone marrow and retinal pigment epithelium (RPE). Isoform L: Isoform L 2 is widely and abundantly expressed all tissues. Isoform 3: Isoform 3 is highly expressed in heart, lung, bone marrow, retina, brain, and RPE. |
| Post Translational Modifications | Isoprenylated. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina. Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells. |
| Protein Name | Ras-Related Protein Rab-28 |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoskeletonCilium Basal BodyNucleusExpressed In The Basal Body And Ciliary Rootlet Of The Photoreceptor CellsLocalized In The Cytoplasm And The Nucleus Of Vascular Endothelial Cells |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-28 antibodyAnti-RAB28 antibody |
Information sourced from Uniprot.org
