Anti-RAB26 antibody (1-60) (STJ118936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAB26 (1-60) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB26 |
| Gene ID | 25837 |
| Uniprot ID | RAB26_HUMAN |
| Immunogen Region | 1-60 |
| Immunogen Sequence | MSRKKTPKSKGASTPAASTL PTANGARPARSGTALSGPDA PPNGPLQPGRPSLGGGVDFY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human RAB26 (NP_055168.2). |
Additional Info
| Tissue Specificity | Predominantly expressed in brain. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. |
| Protein Name | Ras-Related Protein Rab-26 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesicleSecretory Vesicle MembraneNot Localized At The Plasma MembraneInhibition Of S-Geranylgeranyl Cysteine Formation Abolishes Membrane Location |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-26 antibodyAnti-RAB26 antibody |
Information sourced from Uniprot.org